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Published on: June 17, 2013

Chronic handling modifies the anxiolytic effect of diazepam in the elevated plus-maze

R R Brett1, J A Pratt

  • 1Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, U.K.

European Journal of Pharmacology
|March 13, 1990
PubMed

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Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...