Related Experiment Video

Updated: Jun 20, 2026

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
08:28

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

[Analysis of factors influencing QT interval dispersion in patients with stable angina]

N V Furman, S S Shmatova, P Ia Dovgalevskiĭ

    Klinicheskaia Meditsina
    |August 27, 2009
    PubMed

    Insights

    Coronary atherosclerosis severity in stable angina patients correlates with uneven heart repolarization. Factors like hypertension and age contribute to this myocardial repolarization inhomogeneity.

    Area of Science:

    • Cardiology
    • Electrophysiology
    • Medical Imaging

    Background:

    • Stable angina is often linked to coronary atherosclerosis.
    • Myocardial repolarization abnormalities can indicate cardiac disease.
    • Understanding repolarization inhomogeneity is crucial for risk stratification.

    Purpose of the Study:

    • To investigate the link between coronary atherosclerosis severity and spatial repolarization inhomogeneity in stable angina patients.
    • To identify factors influencing myocardial repolarization.
    • To assess the clinical relevance of repolarization dispersion.

    Main Methods:

    • 104 patients with stable angina (FC II-IV) underwent treadmill testing, selective coronarography, and Doppler echocardiography.
    • Spatial inhomogeneity of repolarization was measured using QT and QTa interval dispersion at rest and peak exercise.
    • Factor analysis was employed to analyze spatial dQT data.

    Main Results:

    • Hemodynamically significant coronary atherosclerosis was associated with elevated myocardial repolarization inhomogeneity.
    • Factors contributing to repolarization inhomogeneity included arterial hypertension, left ventricular hypertrophy, age, and patient functional state.
    • Spatial dispersion of repolarization (dQT) at maximum exercise was a key indicator.

    Conclusions:

    • Increased spatial repolarization inhomogeneity is linked to coronary atherosclerosis severity in stable angina.
    • Arterial hypertension, left ventricular hypertrophy, and age are significant contributors to this inhomogeneity.
    • Repolarization dispersion may serve as a marker for assessing the impact of coronary atherosclerosis.

    More Related Videos

    A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis18:11

    A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

    Published on: December 28, 2012

    Related Concept Videos

    Electrocardiogram01:29

    Electrocardiogram

    An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
    Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and the T...
    Angina III: Clinical Manifestations and Assessment01:29

    Angina III: Clinical Manifestations and Assessment

    Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
    ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

    ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

    Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
    Acute Coronary Syndrome III: Diagnostic Studies01:30

    Acute Coronary Syndrome III: Diagnostic Studies

    Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
    Dysrhythmias V: Evaluating Dysrhythmias01:30

    Dysrhythmias V: Evaluating Dysrhythmias

    Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
    Dysrhythmias IV: Characteristics of Bradyarrhythmias01:18

    Dysrhythmias IV: Characteristics of Bradyarrhythmias

    Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...