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Serum IL-6 level may have role in the pathophysiology of unexplained infertility
Bulent Demir1, Suleyman Guven, Emine Seda Guvendag Guven
1Obstetrics and Gynecology Clinic, Health Ministry Ergani Goverment Hospital, Diyarbakir, Turkey. bulentdemirmd@hotmail.com
Problem:
The aim of this study was to compare the serum levels of interleukin (IL)-6 of women with unexplained infertility with fertile subjects.
Method Of Study:
Serum IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels of 45 infertile and 44 fertile women on day 3 of menstrual cycle were assessed and compared for this prospective controlled study.
Results:
The mean serum IL-6 level was significantly higher in women with unexplained infertility, compared with fertile women (5.71 +/- 1.81 and 4.31 +/- 1.79, P < 0.001, Student's t-test). There was no significant difference in TNF-alpha level among the groups.
Conclusion:
Significant difference in serum IL-6 levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility.
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