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Updated: Jun 20, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

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Published on: July 11, 2013

Generalized pustular psoriasis in a 6-week-old infant

Pei-Hsin Chao1, Yu-Wen Cheng, Mei-Yung Chung

  • 1Department of Pediatrics, Section of Neonatology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan.

Pediatric Dermatology
|August 27, 2009
PubMed

Insights

Generalized pustular psoriasis (GPP) is rare in infants. Acitretin effectively treated a 6-week-old infant with GPP, showing it

Area of Science:

  • Pediatric Dermatology
  • Rare Genetic Diseases

Background:

  • Generalized pustular psoriasis (GPP) is a rare, severe skin condition.
  • Infantile GPP presents diagnostic challenges due to differential diagnoses like infections.

Observation:

  • A 6-week-old infant presented with clinical manifestations of GPP.
  • Detailed laboratory and histopathology findings were consistent with GPP.

Findings:

  • Acitretin treatment initiated at 1 mg/kg/day led to significant psoriasis improvement.
  • Dosage was titrated to 0.4 mg/kg/day, maintaining remission for 6 months.

Implications:

  • Acitretin is a viable and effective therapeutic option for infantile GPP.
  • Early diagnosis and treatment are crucial for managing GPP in neonates.

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