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Review article: nuclear receptors and liver disease--current understanding and new therapeutic implications

D A H Elfaki1, E Bjornsson, K D Lindor

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55901, USA.

Alimentary Pharmacology & Therapeutics
|August 27, 2009
PubMed
Abstract

Insights

Targeting nuclear receptors shows promise for treating liver diseases, but understanding their molecular mechanisms is crucial for improving patient outcomes and preventing toxicity. Further research is needed to fully elucidate these complex pathways.

Area of Science:

  • Hepatology
  • Molecular Endocrinology
  • Pharmacology

Background:

  • Nuclear receptors play a critical role in liver function, influencing both normal physiology and disease states.
  • Recent research highlights their significance in understanding and treating liver diseases.

Purpose of the Study:

  • To review novel insights into the molecular basis of liver diseases derived from nuclear receptor studies.
  • To summarize recent research evaluating the therapeutic potential of targeting nuclear receptors for liver diseases.

Main Methods:

  • Comprehensive literature review utilizing PubMed.
  • Analysis of relevant articles and their reference lists.

Main Results:

  • Nuclear receptor ligands in liver disease patients are linked to various toxicities.
  • Clinical outcomes of some nuclear receptor-targeting therapies have not met preclinical expectations.
  • A deeper molecular understanding is required to mitigate toxicity and enhance treatment efficacy.

Conclusions:

  • Targeting nuclear receptors represents a promising therapeutic strategy for numerous liver diseases.
  • Significant gaps remain in fully understanding the molecular mechanisms of nuclear receptor action in liver disease.

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