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Updated: Jun 20, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
On optimal delivery of combination therapy for tumors
Alberto d'Onofrio1, Urszula Ledzewicz, Helmut Maurer
1Department of Experimental Oncology, European Institute of Oncology, 20139 Milan, Italy. alberto.donofrio@ifom-ieo-campus.it
Abstract:
A mathematical model for the scheduling of angiogenic inhibitors in combination with a chemotherapeutic agent is formulated. Conditions are given that allow tumor eradication under constant infusion therapies. Then the optimal scheduling of a vessel disruptive agent in combination with a cytotoxic drug is considered as an optimal control problem. Both theoretical and numerical results on the structure of optimal controls are presented.
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