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Related Concept Videos

Rigid Body Equilibrium Problems - II01:21

Rigid Body Equilibrium Problems - II

A rigid body is in static equilibrium when the net force and the net torque acting on the system are equal to zero.
Consider two children sitting on a seesaw, which has negligible mass. The first child has a mass (m1) of 26 kg and sits at point A, which is 1.6 meters (r1) from the pivot point B; the second child has a mass (m2) of 32 kg and sits at point C. How far from the pivot point B should the second child sit (r2) to balance the seesaw?
Equilibrium and Balance01:15

Equilibrium and Balance

The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
Frames: Problem Solving II01:26

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Consider a hydraulic hoist supporting a load of 1 kN. Assuming a simplified schematic representation of this frame structure, the force acting on BD and BF members can be determined.
Static Equilibrium - II01:07

Static Equilibrium - II

Static equilibrium is a special case in mechanics that is very important in everyday life. It occurs when the net force and the net torque on an object or system are both zero. This means that both the linear and angular accelerations are zero. Thus, the object is at rest, or its center of mass is moving at a constant velocity. However, this does not mean that no forces are acting on the object within the system. In fact, there are very few scenarios on Earth in which no forces are acting upon...
Stability of Equilibrium Configuration: Problem Solving01:13

Stability of Equilibrium Configuration: Problem Solving

The stability of equilibrium configurations is an important concept in physics, engineering, and other related fields. In simple terms, it refers to the tendency of an object or system to return to its equilibrium position after being disturbed. The stability of an equilibrium configuration can be analyzed by considering the potential energy function of the system and examining its behavior near the equilibrium point.
Problem-solving in the context of the stability of equilibrium configuration...
Machines: Problem Solving II01:30

Machines: Problem Solving II

Machines are complex structures consisting of movable, pin-connected multi-force members that work together to transmit forces. Consider a lifting tong carrying a 100 kg load. It comprises movable sections DAF and CBG linked together with member AB.

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Related Experiment Video

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A Vibrotactile Feedback Device for Seated Balance Assessment and Training
09:13

A Vibrotactile Feedback Device for Seated Balance Assessment and Training

Published on: January 20, 2019

Dynamic balancing: DEPTOR tips the scales.

Christopher G Proud1

  • 1School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK. c.g.proud@soton.ac.uk

Journal of Molecular Cell Biology
|August 27, 2009
PubMed
Summary
This summary is machine-generated.

Researchers discovered a new regulator of the mammalian target of rapamycin (mTOR) pathway. This finding is significant for understanding cellular regulation and developing treatments for cancers like multiple myeloma.

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Last Updated: Jun 20, 2026

A Vibrotactile Feedback Device for Seated Balance Assessment and Training
09:13

A Vibrotactile Feedback Device for Seated Balance Assessment and Training

Published on: January 20, 2019

A Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance
07:19

A Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance

Published on: March 19, 2020

Area of Science:

  • Cellular Biology
  • Molecular Oncology
  • Signal Transduction

Background:

  • The mammalian target of rapamycin (mTOR) is a critical regulator of cellular processes.
  • Dysregulation of mTOR signaling is implicated in various diseases, particularly cancers.
  • Understanding mTOR's regulatory network is crucial for therapeutic development.

Purpose of the Study:

  • To identify novel binding partners and regulators of mTOR.
  • To investigate the functional impact of a newly identified mTOR regulator on downstream signaling.
  • To explore the role of this regulator in cancer, specifically multiple myeloma.

Main Methods:

  • Affinity purification coupled with mass spectrometry to identify mTOR-interacting proteins.
  • Western blotting and immunoprecipitation assays to confirm protein interactions.
  • Cell-based assays to assess signaling pathway modulation.

Main Results:

  • A novel protein partner and regulator of mTOR was identified.
  • This new regulator was shown to influence the balance of signaling pathways downstream of mTOR.
  • The identified regulator plays a role in the pathogenesis of multiple myeloma.

Conclusions:

  • The discovery of a new mTOR regulator expands our understanding of cellular signaling networks.
  • This finding provides a potential new therapeutic target for mTOR-dysregulated cancers, including multiple myeloma.