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An opioid agonist with preference for kappa-opioid receptors: (-)-N-cyclopropylmethylmorphinan-6-one
H Schmidhammer1, E Trenker, W P Burkard
1Institute of Organic and Pharmaceutical Chemistry, University of Innsbruck, Austria.
Archiv Der Pharmazie
|January 1, 1990
Abstract:
N-Cyclopropylmethyl- and N-cyclobutylmethylmorphinan-6-one (3 and 4, respectively) were prepared from N-methylmorphinan-6-one. The pharmacological studies showed 3 and 4 to be potent opioid agonists. Compound 3 was found to have preference for kappa rather than mu opioid receptors.