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Infliximab in ulcerative colitis

Avi Levin1, Oren Shibolet

  • 1Gastroenterology and Liver Units, Division of Medicine, Hadassah-Hebrew University Medical center, Jerusalem, Israel.

Biologics : Targets & Therapy
|August 27, 2009
PubMed

Infliximab, a monoclonal anti-TNF-alpha antibody, is commonly used for treatment of moderate to severe Crohn's disease (CD). Its role in the treatment for ulcerative colitis (UC) remains controversial. We review the role of TNF-alpha in the pathogenesis of UC and describe the randomized, double-blind, placebo-controlled trials and systematic reviews that assess the efficacy of infliximab in the treatment of moderate to severe UC.

Keywords:
anti-TNF-α antibodycrohn’s diseaseinfliximabulcerative colitis

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