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Updated: Jun 20, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[Lung impairment in systemic sclerosis].
1Medizinische Klinik III - Pneumologie, Allergologie, Schlaf- und Beatmungsmedizin, Berufsgenossenschaftliche Universitätsklinik Bergmannsheil GmbH, Klinikum der Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, Bochum. Heiko.Knoop@ruhr-uni-bochum.de
Systemic sclerosis (SSc) often causes lung impairments like interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH). This review covers SSc lung disease forms, pathogenesis, and current treatments.
Area of Science:
- Rheumatology and Immunology
- Pulmonology
Context:
- Scleroderma, a connective tissue disease, encompasses systemic sclerosis (SSc).
- Lung involvement, including interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH), is a frequent and serious complication in SSc patients.
Purpose:
- To summarize the various forms of lung impairment in SSc.
- To highlight the pathogenesis of SSc-related lung diseases.
- To review current therapeutic strategies for lung manifestations in SSc.
Summary:
- SSc presents with diverse lung conditions, primarily ILD and PAH.
- Understanding the pathogenetic mechanisms is crucial for targeted therapies.
- Current treatment options focus on managing inflammation and preventing disease progression.
Impact:
- Provides a comprehensive overview of SSc-associated lung diseases for clinicians and researchers.
- Aids in identifying potential therapeutic targets and improving patient management.
- Contributes to the knowledge base on scleroderma complications and treatment outcomes.
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