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Related Concept Videos

Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
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Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
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Chronic Obstructive Pulmonary Disease II: Emphysema

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Chronic Kidney Disease II: Clinical Manifestations

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Related Experiment Video

Updated: Jun 20, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

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Published on: June 16, 2020

[Lung impairment in systemic sclerosis].

H Knoop1, U Arinir, A Kreuter

  • 1Medizinische Klinik III - Pneumologie, Allergologie, Schlaf- und Beatmungsmedizin, Berufsgenossenschaftliche Universitätsklinik Bergmannsheil GmbH, Klinikum der Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, Bochum. Heiko.Knoop@ruhr-uni-bochum.de

Pneumologie (Stuttgart, Germany)
|August 27, 2009
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis (SSc) often causes lung impairments like interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH). This review covers SSc lung disease forms, pathogenesis, and current treatments.

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Area of Science:

  • Rheumatology and Immunology
  • Pulmonology

Context:

  • Scleroderma, a connective tissue disease, encompasses systemic sclerosis (SSc).
  • Lung involvement, including interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH), is a frequent and serious complication in SSc patients.

Purpose:

  • To summarize the various forms of lung impairment in SSc.
  • To highlight the pathogenesis of SSc-related lung diseases.
  • To review current therapeutic strategies for lung manifestations in SSc.

Summary:

  • SSc presents with diverse lung conditions, primarily ILD and PAH.
  • Understanding the pathogenetic mechanisms is crucial for targeted therapies.
  • Current treatment options focus on managing inflammation and preventing disease progression.

Impact:

  • Provides a comprehensive overview of SSc-associated lung diseases for clinicians and researchers.
  • Aids in identifying potential therapeutic targets and improving patient management.
  • Contributes to the knowledge base on scleroderma complications and treatment outcomes.