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Related Concept Videos

Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...

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Microfabricated Post-Array-Detectors (mPADs): an Approach to Isolate Mechanical Forces
61:34

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Published on: October 1, 2007

Pillar array microtraps with negative dielectrophoresis.

Hai-Hang Cui1, Kian-Meng Lim

  • 1Singapore-MIT Alliance and Department of Mechanical Engineering, National University of Singapore, Singapore 119260. smach@nus.edu.sg

Langmuir : the ACS Journal of Surfaces and Colloids
|August 27, 2009
PubMed
Summary
This summary is machine-generated.

This study introduces a microfluidic particle-trap array using negative dielectrophoresis (nDEP) and hydrodynamic forces for precise particle manipulation. The novel design enables accurate control over single and multiple particle trapping, demonstrating size discrimination capabilities.

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Area of Science:

  • Microfluidics
  • Biotechnology
  • Nanotechnology

Background:

  • Microfluidic devices are crucial for precise manipulation of small particles.
  • Dielectrophoresis offers label-free particle manipulation.
  • Controlling particle numbers in traps remains a challenge.

Purpose of the Study:

  • To develop a microfluidic particle-trap array.
  • To utilize negative dielectrophoresis (nDEP) and hydrodynamic forces for particle trapping.
  • To achieve accurate control over single and multiparticle trapping, including size discrimination.

Main Methods:

  • Designing a microfluidic chip with an array of cylindrical pillars.
  • Employing negative dielectrophoresis (nDEP) and hydrodynamic forces.
  • Utilizing pulsed nDEP for enhanced selectivity and stability.
  • Validating the design with 5 micrometer polystyrene beads.

Main Results:

  • Demonstrated a microfluidic particle-trap array capable of single and multiparticle trapping.
  • Achieved accurate control over the number of trapped particles by adjusting force balance.
  • Showcased particle size discrimination capabilities.
  • Observed good correlation between simulated and experimental results.

Conclusions:

  • The developed microfluidic particle-trap array offers precise and controllable particle trapping.
  • The combination of nDEP and hydrodynamic forces provides accurate manipulation.
  • Pulsed nDEP enhances the selectivity and stability of particle trapping.