[Obesity and development of metabolic syndrome in androgen-deficient young men]

Results of this study and literature data provide convincing evidence of the association between metabolic syndrome and male hypogonadism. International studies demonstrated beneficial effect of exogenous testosterone on body mass, lipid metabolism, insulin secretion and sensitivity as well as reduction of AP and fat tissue volume, i.e. normalization of major parameters compromised in patients with metabolic syndrome. Also, compensation of decreased endogenous testosterone level by administration of its synthetic analogs may improve reproductive health in men. A significant decrease of testosterone production in young men should be regarded as an additional sign of metabolic syndrome.