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Establishing Fungal Entomopathogens as Endophytes: Towards Endophytic Biological Control
Published on: April 11, 2013
Spirobisnaphthalene analogues from the endophytic fungus Preussia sp
Xiaomei Chen1, Qiyuan Shi, Geng Lin
1Biotechnology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Abstract:
A study on the chemical constituents of the endophytic fungus Preussia sp. led to the isolation of three new spirobisnaphthalene analogues, spiropreussione A (1), spiropreussione B (2), and spiropreussomerin A (3). Compound 2 is a spirobisnaphthalene analogue with a cyclopenteno-naphthoindene fragment bridged to a 1,8-dioxygenated naphthalene fragment, and compound 1 is the second compound in this series with a spiro-nonadiene skeleton. The structures of 1-3 were elucidated using spectroscopic data interpretation. Compound 1 showed cytotoxicity toward A2780 and BEL-7404 cells with IC(50) values of 2.4 and 3.0 microM, respectively, and weak activity against Staphylococcus aureus (CMCC B26003) with a MIC value of 25 microM.
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