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Updated: Jun 20, 2026
04:04
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
How many cisplatin administration protocols does your department use?
A P Greystoke1, D I Jodrell, M Cheung
1Edinburgh Cancer Centre, Western General Hospital, Edinburgh, Scotland, UK.
European Journal of Cancer Care
|August 28, 2009
Summary
Cisplatin hydration protocols have evolved, leading to significant practice variations. This review highlights the need for evidence-based guidelines to standardize patient care and optimize cisplatin treatment.
Area of Science:
- Oncology
- Nephrology
- Clinical Pharmacy
Background:
- Cisplatin administration requires hydration and diuresis to manage toxicity.
- Evolving hydration protocols aim for patient comfort and resource efficiency.
- Observed variations in clinical practice suggest a need for standardization.
Purpose of the Study:
- To review current cisplatin hydration practices.
- To identify variations in hydration protocols.
- To recommend evidence-based guidelines for future protocols.
Main Methods:
- Retrospective review of hydration protocols at Edinburgh Cancer Centre.
- Analysis of variations in fluid administration, cisplatin dilution, and supportive care.
- Evidence review of existing cisplatin hydration regimens.
Main Results:
- Identified 25 different hydration protocols in use.
- Observed wide variations in fluid volume, cisplatin dilution, electrolyte supplementation, and diuretic use.
- Variations appear linked to published clinical trial protocols.
Conclusions:
- Significant heterogeneity exists in current cisplatin hydration protocols.
- Standardization based on evidence is crucial for consistent patient care.
- Development of evidence-based protocols is recommended to optimize cisplatin therapy.
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