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Related Experiment Video

Updated: Jun 20, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

How many cisplatin administration protocols does your department use?

A P Greystoke¹, D I Jodrell, M Cheung

¹Edinburgh Cancer Centre, Western General Hospital, Edinburgh, Scotland, UK.

European Journal of Cancer Care

|August 28, 2009

Summary

Cisplatin hydration protocols have evolved, leading to significant practice variations. This review highlights the need for evidence-based guidelines to standardize patient care and optimize cisplatin treatment.

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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

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Published on: February 12, 2017

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Area of Science:

Oncology
Nephrology
Clinical Pharmacy

Background:

Cisplatin administration requires hydration and diuresis to manage toxicity.
Evolving hydration protocols aim for patient comfort and resource efficiency.
Observed variations in clinical practice suggest a need for standardization.

Purpose of the Study:

To review current cisplatin hydration practices.
To identify variations in hydration protocols.
To recommend evidence-based guidelines for future protocols.

Main Methods:

Retrospective review of hydration protocols at Edinburgh Cancer Centre.
Analysis of variations in fluid administration, cisplatin dilution, and supportive care.
Evidence review of existing cisplatin hydration regimens.

Main Results:

Identified 25 different hydration protocols in use.
Observed wide variations in fluid volume, cisplatin dilution, electrolyte supplementation, and diuretic use.
Variations appear linked to published clinical trial protocols.

Conclusions:

Significant heterogeneity exists in current cisplatin hydration protocols.
Standardization based on evidence is crucial for consistent patient care.
Development of evidence-based protocols is recommended to optimize cisplatin therapy.