Related Experiment Video
Updated: Jun 20, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Decreasing amputation rates in patients with diabetes-a population-based study
C J Schofield1, N Yu, A S Jain
1Ninewells Hospital and Medical School, Dundee, UK. cschofield@nhs.net
Aims:
To assess the changing rate of amputation in patients with diabetes over a 7-year period.
Methods:
All patients undergoing lower extremity amputation in Tayside, Scotland between 1 January 2000 and 31 December 2006 were identified. Temporal linkage of cases to the diabetes database was used to ascertain which amputations were in patients with diabetes.
Results:
The incidence of major amputations fell from 5.1 [95% confidence interval (CI) 3.8-6.4] to 2.9 (95% CI 1.9-3.8) per 1000 patients with diabetes (P < 0.05). There is a clear linear trend in the adjusted incidence of major amputation (P = 0.023 and 0.027 for age- and sex-adjusted, and duration- and sex-adjusted incidences, respectively). The adjusted incidence of total amputations followed decreased linear regression trend over the whole study period when adjusted for age and sex or diabetes duration and sex (P = 0.002).
Conclusions:
There has been a significant reduction in the incidence of major lower extremity amputation in patients with diabetes over the 7-year period.
Related Concept Videos
Diabetic Foot Ulcer
Diabetic Retinopathy
Complications of Diabetes Mellitus
Peripheral Artery Disease V: Postoperative Nursing Management
Type II Diabetes II: Pathophysiology
Type I Diabetes II: Pathophysiology