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Plasma and cerebrospinal fluid concentration of temazepam following oral drug administration
N R Badcock1, G A Osborne, T L Nyman
1Department of Chemical Pathology, Adelaide Children's Hospital, South Australia.
European Journal of Clinical Pharmacology
|January 1, 1990
Abstract:
Thirteen male patients were administered 20 mg of temazepam orally 1 to 2 h prior to undergoing spinal anaesthesia for a urological procedure. Samples of blood and CSF were drawn just before insertion of the spinal and the concentration of drug estimated in these two media. The results obtained indicated that a highly significant correlation existed between the unbound concentration of temazepam in plasma and the concentration of drug present in CSF. Temazepam appeared to be an effective light pre-medicant in all of the subjects studied.