Related Experiment Videos
A new EcoRI polymorphism at the D21S13 locus.
S M Pulst1, J R Korenberg, J Greenwald
1Division of Neurology, Cedars-Sinai Medical Center, University of California, Los Angeles 90048.
Human Genetics
|May 1, 1990
Summary
Researchers identified a new EcoRI polymorphism at the D21S13 locus. This finding aids in studying familial Alzheimer disease (FAD) families and precise FAD gene mapping.
Area of Science:
- Genetics
- Neuroscience
- Molecular Biology
Background:
- The D21S13 locus on chromosome 21 is linked to familial Alzheimer disease (FAD).
- Previous probes for this locus had limited informativeness, hindering precise genetic mapping and heterogeneity analysis in FAD.
Purpose of the Study:
- To describe a new EcoRI polymorphism at the D21S13 locus.
- To provide a more informative tool for studying familial Alzheimer disease.
Main Methods:
- Genetic analysis of the D21S13 locus.
- Identification and characterization of a novel EcoRI polymorphism.
Main Results:
- A new EcoRI polymorphism at the D21S13 locus has been identified.
- This polymorphism offers improved informativeness compared to previously available probes.
Conclusions:
- The newly identified EcoRI polymorphism at D21S13 is a valuable tool for FAD research.
- This discovery facilitates more precise mapping of the FAD locus and analysis of genetic heterogeneity in Alzheimer disease families.