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TMP21 transmembrane domain regulates gamma-secretase cleavage

Raphaëlle Pardossi-Piquard1, Christopher Böhm, Fusheng Chen

  • 1Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5S 3H2, Canada.

The Journal of Biological Chemistry
|August 28, 2009
PubMed
Summary

TMP21 protein regulates gamma-secretase activity by binding to the presenilin complex. Its transmembrane domain is key to inhibiting amyloid-beta production, offering insights into gamma-secretase modulation.

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