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Up-regulation of integrin expression in lung adenocarcinoma cells caused by bacterial infection: in vitro study

Sean Gravelle1, Rebecca Barnes, Nicole Hawdon

  • 1Medical Sciences Division, Northern Ontario School of Medicine West Campus, Ontario, Canada, Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada.

Innate Immunity
|August 28, 2009
PubMed

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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