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Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Modified proteins in allergy prevention.

Andrea von Berg1

  • 1Research Institute, Children's Department, Marien Hospital-Wesel, Abteilung für Kinderheilkunde, Wesel, Germany. vonberg@marien-hospital-wesel.de

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Summary
This summary is machine-generated.

Hydrolyzed formulas, including partially (pHF) and extensively (eHF) hydrolyzed cow's milk proteins, show potential in preventing early-onset allergies like atopic eczema in high-risk infants.

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Area of Science:

  • Allergy and Immunology
  • Pediatric Nutrition
  • Gastroenterology

Background:

  • Cow's milk protein hypersensitivity affects approximately 2.5% of neonates, often linked to early milk exposure.
  • Hydrolyzed infant formulas (pHF, eHF) are developed to mitigate allergy risk in high-risk infants needing supplementation.
  • The efficacy of hydrolyzed formulas may depend on both the degree and process of protein hydrolysis.

Purpose of the Study:

  • To evaluate the allergy-preventive potential of partially and extensively hydrolyzed cow's milk formulas.
  • To differentiate the indications for pHF and eHF in primary and secondary allergy prevention.
  • To assess the trend of atopy reduction in children using hydrolyzed formulas.

Main Methods:

  • Review of clinical trials investigating hydrolyzed cow's milk formulas (pHF, eHF).
  • Analysis of outcomes related to atopy, specifically atopic eczema and food allergy.
  • Comparison of hydrolyzed formulas' efficacy based on hydrolysis degree and process.

Main Results:

  • Certain pHFs and eHFs demonstrated a trend toward reducing atopy, primarily atopic eczema and food allergy, in children up to age 6.
  • Partially hydrolyzed formulas (pHF) and extensively hydrolyzed formulas (eHF) show promise for primary allergy prevention in high-risk infants.
  • Extensively hydrolyzed formulas (eHF) are indicated for secondary prevention in infants with diagnosed cow's milk allergy.

Conclusions:

  • Hydrolyzed cow's milk formulas can be considered for primary allergy prevention in infants requiring supplementation, even without a family history of atopy.
  • The choice between pHF and eHF depends on whether it's for primary or secondary prevention of allergies.
  • Further consideration of hydrolysates for all supplemented infants may be warranted given the high prevalence of allergy in children without a family history.