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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Updated: Jun 20, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Multifocal osteosarcoma in childhood.

Beate Kunze1, Steffen Bürkle, Torsten Kluba

  • 1Orthopaedic Department, University of Tuebingen, 72076 Tübingen, Germany.

La Chirurgia Degli Organi Di Movimento
|August 28, 2009
PubMed
Summary

Multifocal osteosarcoma, a rare bone cancer in children, presents unique challenges. Early chemotherapy response and aggressive surgery show promise but survival remains linked to initial tumor response.

Area of Science:

  • Pediatric Oncology
  • Skeletal Oncology
  • Tumor Biology

Background:

  • Osteosarcoma is a primary malignant bone tumor common in children, typically affecting long bone metaphyses.
  • Multifocal osteosarcoma, a rare variant (0.5-4%), presents with multiple bone lesions, sometimes without pulmonary metastases, and carries a poor prognosis.

Observation:

  • This report details two pediatric cases of multifocal synchronous osteosarcoma in 14-year-olds.
  • Both cases exhibited multiple bone lesions without initial pulmonary metastases.
  • Treatment involved neoadjuvant chemotherapy, oncologic surgery, and adjuvant chemotherapy.

Findings:

  • Tumor response to chemotherapy varied, being good in one patient and poor in the other.
  • Complete tumor resection (R0) was achieved in both patients.

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  • Disease recurrence, marked by pulmonary metastases, occurred within one year for both.

    • Implications:

    • Combining chemotherapy and aggressive surgery has improved multifocal osteosarcoma prognosis.
    • Initial histological response to chemotherapy appears to be a critical factor for patient survival.
    • Further research is needed to optimize treatment strategies for this rare condition.