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Matrix metalloproteinase-2 inhibitors from Clinopodium chinense var. parviflorum
Toshihiro Murata1, Kenroh Sasaki, Kumiko Sato
1Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
Journal of Natural Products
|August 29, 2009
Abstract:
From the aerial parts of Clinopodium chinense var. parviflorum, nine new phenylpropanoids, clinopodic acids A-I (2-10), were isolated together with a known phenylpropanoid, rosmarinic acid (1). The structures of these new compounds were elucidated on the basis of spectroscopic analysis. Clinopodic acid C (4) showed MMP-2 inhibitory activity (IC(50) 3.26 microM).