Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac hypertrophy in hypertension.

R Cífková1, P Frídl, J Skibová

  • 1Postgraduate Medical and Pharmaceutical Institute, Czechoslovak Academy of Sciences, Prague.

Cor Et Vasa
|January 1, 1990
PubMed
Summary

Antihypertensive treatment effectively reduces left ventricular hypertrophy (LVH) in middle-aged patients. Regression of LVH occurred rapidly, particularly within the first three months, without negatively impacting left ventricular function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of severe diabetic kidney disease on the clinical outcome of autologous cell therapy in people with diabetes and critical limb ischaemia.

Diabetic medicine : a journal of the British Diabetic Association·2019
Same author

Severe Epidermal Nerve Fiber Loss in Diabetic Neuropathy Is Not Reversed by Long-Term Normoglycemia After Simultaneous Pancreas and Kidney Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Portal versus systemic venous drainage of the pancreatic graft: the effect on glucose metabolism in pancreas and kidney transplant recipients.

Transplantation proceedings·2014
Same author

Effect of tacrolimus versus cyclosporine on glucose metabolism of pancreas and kidney recipients in the late (> 8 years) posttransplant period.

Transplantation proceedings·2011
Same author

Biventricular pacing in the early postoperative period after cardiac surgery.

Physiological research·2011
Same author

The influence of vascular endothelial growth factor (VEGF) polymorphism on the progression of chronic glomerulonephritides.

Folia biologica·2011

Area of Science:

  • Cardiology
  • Hypertension Research
  • Medical Imaging

Background:

  • Left ventricular hypertrophy (LVH) is a common complication of hypertension.
  • Understanding the time course and factors influencing LVH regression is crucial for patient management.
  • Echocardiography plays a key role in assessing cardiac structure and function in hypertensive individuals.

Purpose of the Study:

  • To investigate the regression of left ventricular hypertrophy (LVH) in hypertensive patients.
  • To analyze changes in left ventricular function during antihypertensive therapy.
  • To compare the effects of beta-blockers and methyldopa on LVH regression.

Main Methods:

  • A three-year follow-up study involving 52 middle-aged hypertensive patients.
  • Patients were treated with either beta-blockers or methyldopa, with additions of diuretics/vasodilators as needed.

Related Experiment Videos

  • Echocardiography was used to measure left ventricular mass, posterior wall thickness, and interventricular septum thickness.

    • Main Results:

    • Significant blood pressure reduction was observed, most pronounced in the first three months.
    • The greatest decrease in posterior wall and interventricular septum thickness occurred within the first three months.
    • Complete regression of posterior wall hypertrophy was seen within six months; septum regression continued for two years. Overall, 57.7% showed complete regression, with incomplete regression in 38.4% of obese patients.

    Conclusions:

    • Antihypertensive therapy leads to significant regression of left ventricular hypertrophy (LVH) in hypertensive patients.
    • LVH regression is a relatively rapid process, particularly in the initial months of treatment.
    • Regression of LVH was not associated with deterioration of left ventricular function and occurred irrespective of specific drug classes used.