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Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
Published on: April 11, 2017
An elasto-visco-plastic model of cell aggregates.
L Preziosi1, D Ambrosi, C Verdier
1Department of Mathematics - Politecnico di Torino, Italy. preziosi@polito.it
Journal of Theoretical Biology
|August 29, 2009
Summary
This study introduces a new elasto-visco-plastic model for concentrated cell suspensions. The model accurately describes cell aggregate mechanics, including yield stress, aligning with experimental data.
Area of Science:
- Rheology
- Biophysics
- Materials Science
Background:
- Concentrated cell suspensions display complex mechanical behaviors, including elastic, viscoelastic, and adhesive properties.
- The fluid medium is typically Newtonian, contrasting with the cells' rheological nature.
Purpose of the Study:
- To develop and validate a novel elasto-visco-plastic model for concentrated cell suspensions and aggregates.
- To link the macroscopic constitutive equation's yield stress to the microscopic rearrangement of adhesion bonds.
Main Methods:
- Development of a new elasto-visco-plastic constitutive model.
- Comparison of model predictions against five distinct experimental tests.
Main Results:
- The model successfully describes the mechanical properties of concentrated cell suspensions.
- Predictions align with experimental data from steady shear rate, oscillatory shearing, stress relaxation, elastic recovery, and uniaxial compression tests.
Conclusions:
- The proposed elasto-visco-plastic model provides a robust framework for understanding cell aggregate mechanics.
- The model's success in matching experimental results validates the proposed link between bond rearrangement and yield stress.
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