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Related Experiment Video

Updated: Jun 20, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

Hyperaldosteronism and hyperprogesteronism in a cat.

Katherine Briscoe¹, Vanessa R Barrs, Darren F Foster

¹Valentine Charlton Cat Centre, Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia.

Journal of Feline Medicine and Surgery

|August 29, 2009

Summary

This summary is machine-generated.

This case study details a cat with concurrent hyperaldosteronism and hyperprogesteronism, presenting with hair loss and muscle wasting. Early recognition of adrenal tumors is crucial for managing these complex feline endocrine disorders.

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Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

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Published on: March 12, 2019

Area of Science:

Veterinary Medicine
Endocrinology
Oncology

Background:

This report describes the second known case of concurrent hyperaldosteronism and hyperprogesteronism in a cat.
Adrenal tumors can lead to complex endocrine imbalances, requiring clinical vigilance.

Observation:

A 14-year-old cat presented with progressive hair loss, muscle wasting, hind limb weakness, and hypertension.
Clinical signs included a pot-bellied appearance, skin fragility, symmetrical alopecia, and a gallop rhythm.
Abdominal ultrasound revealed a large left adrenal mass.

Findings:

Primary hyperaldosteronism was diagnosed via elevated plasma aldosterone and normal plasma renin activity.
Hyperprogesteronism was confirmed through an adrenocorticotrophic hormone stimulation test.
Biochemical abnormalities included azotaemia, hypochloridaemia, hypokalaemia, metabolic alkalosis, and elevated creatine kinase.

Implications:

Concurrent hyperaldosteronism and hyperprogesteronism should be considered in cats with adrenal tumors and related clinical signs.
Neoplastic cells in the adrenal gland may concurrently secrete aldosterone and progesterone, or overproduce progesterone from zona glomerulosa cells.
This case highlights the importance of recognizing and diagnosing rare dual endocrine conditions in feline oncology and endocrinology.