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Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex.

Luigi D'Argenzio¹, Giacomo Koch, Roberta Bombardieri

¹Paediatric Neurology and Psychiatry Unit, Neuroscience Department, Tor Vergata University, Rome, Italy. luigi.d.argenzio@uniroma2.it

Epilepsy Research

|August 29, 2009

Summary

Tuberous Sclerosis Complex (TSC) patients show altered brain connectivity. Non-medicated TSC patients had abnormal posterior parietal cortex (PPC) to motor cortex (M1) connection excitability, suggesting a role in epilepsy.

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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Area of Science:

Neuroscience
Neurology
Medical research

Background:

Tuberous Sclerosis Complex (TSC) is a genetic disorder.
Abnormal brain connectivity is a suspected factor in TSC pathophysiology.
The posterior parietal cortex (PPC) and motor cortex (M1) are crucial for motor control and cognitive functions.

Purpose of the Study:

To investigate the functional connectivity between the PPC and M1 in individuals with TSC.
To compare brain connectivity in non-medicated TSC patients, medicated TSC patients, and healthy controls.
To explore the potential link between altered PPC-M1 connectivity and the epileptic phenotype in TSC.

Main Methods:

Utilized a twin-coil Transcranial Magnetic Stimulation (TMS) protocol.
Assessed the excitability of the connection between the PPC and M1.
Compared results across three groups: healthy subjects, TSC patients on antiepileptic drugs, and non-medicated TSC patients.

Main Results:

Non-medicated TSC patients demonstrated significantly abnormal excitability in the PPC-M1 connection.
This abnormality was distinct when compared to both healthy individuals and TSC patients receiving antiepileptic drug treatment.
Suggests a specific alteration in neural pathways in untreated TSC.

Conclusions:

Altered connectivity between the PPC and M1 is present in Tuberous Sclerosis Complex.
This abnormal excitability in non-medicated patients may contribute to the development or manifestation of epilepsy in TSC.
Findings highlight the importance of investigating neural connectivity in TSC pathophysiology and treatment.