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Updated: Jun 20, 2026
06:04
Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
Published on: February 9, 2016
Permeability of technical and biological tissues
R P Franke1, R Fuhrmann, B Hiebl
1Abt. Biomaterialien, Universität Ulm, Ulm, Germany.
Clinical Hemorheology and Microcirculation
|August 29, 2009
Summary
Material permeability, crucial for tissue and organ function, measures substance passage. A new system precisely assesses native and engineered tissue permeability, offering vital insights into biological processes.
Area of Science:
- Biomedical Engineering
- Physiology
- Materials Science
Background:
- Permeability quantifies substance passage through materials, vital for biological systems.
- Vascular prostheses (e.g., Dacron, ePTFE) exhibit varying permeability, impacting function.
- Capillary permeability governs nutrient, gas exchange, and organ supply, influenced by endothelial cell binding.
Purpose of the Study:
- To define and quantify material permeability in biological contexts.
- To highlight the role of vascular and capillary permeability in physiological processes.
- To introduce a novel system for precise assessment of tissue permeability.
Main Methods:
- Defining permeability based on substance passage over time and area.
- Comparing permeability rates of different vascular prostheses.
- Investigating the influence of interendothelial binding on vascular permeability.
- Utilizing a new system for precise permeability assessment of native and engineered tissues.
Main Results:
- Permeability varies significantly between high-porous (Dacron) and low-porous (ePTFE) vascular prostheses.
- Interendothelial binding critically affects vascular permeability, with rapid changes observed.
- A new system enables precise measurement of tissue permeability.
- Permeability serves as an integral indicator of tissue and organ health.
Conclusions:
- Material permeability is a fundamental property with significant implications in medicine and biotechnology.
- Precise assessment of tissue permeability is achievable with advanced systems.
- Understanding and measuring permeability are key to evaluating tissue and organ function.
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