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Updated: Jun 20, 2026
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Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
Published on: January 9, 2026
Thrombus size and Doppler embolic signal intensity
Matthew J Martin1, Emma M L Chung, Kumar V Ramnarine
1University Hospitals of Leicester NHS Trust, Leicester, UK.
Cerebrovascular Diseases (Basel, Switzerland)
|August 29, 2009
Summary
Doppler ultrasound can estimate thrombus size in cerebral arteries, a common stroke cause. This study found strong correlations between embolus size, signal intensity, and duration, enabling better stroke monitoring.
Area of Science:
- Medical Ultrasound
- Cerebrovascular Disease
- Biomedical Engineering
Background:
- Cerebral artery thrombus emboli are a frequent cause of stroke.
- Doppler ultrasound detects emboli but cannot estimate their size.
- Current methods lack the ability to determine embolus size from ultrasound signals.
Purpose of the Study:
- To investigate the relationship between thrombus size and Doppler ultrasound embolic signal intensity.
- To explore methods for estimating thrombus size in vivo using ultrasound.
- To aid in sizing detected thrombi following carotid surgery.
Main Methods:
- Fresh thrombi were created using the Chandler loop method.
- 390 Doppler embolic signals were measured from 37 thrombi in a pulsatile flow circuit.
- Thrombus dimensions were measured optically; relationships with signal properties were statistically analyzed.
Main Results:
- Embolic signal intensity generally increased with thrombus size.
- Strong positive correlations (r > 0.8, p < 0.01) were found between embolus diameter, signal intensity, and duration.
- Resonance effects caused signal oscillations, influencing intensity.
Conclusions:
- Experimental data support theoretical predictions linking Doppler signal intensity to thrombus size.
- The findings suggest a potential method for sizing emboli in clinical practice.
- This research could improve monitoring of thrombi detected after carotid surgery.
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01:19Assessing Blood pressure using a doppler ultrasound
To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
01:30Equipments Used To Measure Blood Pressure
Direct Method
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...