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Tolerance checkpoints in B-cell development: Johnny B good.

Roxane Tussiwand¹, Nabil Bosco, Rhodri Ceredig

¹Developmental and Molecular Immunology, Department of Biomedicine, University of Basel, Mattenstrasse, Basel, Switzerland.

European Journal of Immunology

|August 29, 2009

Summary

This summary is machine-generated.

B-cell development involves checkpoints in the bone marrow and spleen to eliminate self-reactive cells. Recent findings suggest the large pre-BII stage is also a critical B-cell tolerance checkpoint.

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Area of Science:

Immunology
Cell Biology

Background:

B-cell development occurs in the bone marrow and spleen.
Immature B cells undergo checkpoints to prevent autoimmunity.

Purpose of the Study:

To review B-cell tolerance checkpoints.
To highlight the large pre-BII stage as a novel checkpoint.

Main Methods:

Literature review of B-cell development and tolerance.
Analysis of B-cell differentiation stages and checkpoints.

Main Results:

Immature B-cell and transitional B-cell stages are known checkpoints.
The large pre-BII stage, expressing pre-BCR, is identified as a tolerance checkpoint.

Conclusions:

B-cell tolerance is enforced at multiple stages.
The pre-BCR expression stage is crucial for preventing autoimmunity.