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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and cytotoxicity studies of new cryptophycin analogues
Wen Lu Liu1, Jian Cun Zhang, Fa Qin Jiang
1School of Pharmacy, Shanghai Jiaotong University, Shanghai, P.R. China.
Archiv Der Pharmazie
|August 29, 2009
Abstract:
Two analogues of cryptophycin were synthesized and biologically evaluated for their in-vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC(50 )values in the muM-range, and compound 4 was more effective than compound 3 in most assays studied.
