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Updated: Jun 20, 2026

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
Published on: July 17, 2021
Molecular fingerprint recombination: generating hybrid fingerprints for similarity searching from different
Britta Nisius1, Jürgen Bajorath
1Department of Life Science Informatics, B-IT, Rheinische Friedrich-Wilhelms-Universität Bonn, Germany.
Abstract:
Molecular fingerprints have a long history in computational medicinal chemistry and continue to be popular tools for similarity searching. Over the years, a variety of fingerprint types have been introduced. We report an approach to identify preferred bit subsets in fingerprints of different design and "recombine" these bit segments into "hybrid fingerprints". These compound class-directed fingerprint representations are found to increase the similarity search performance of their parental fingerprints, which can be rationalized by the often complementary nature of distinct fingerprint features.
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