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Updated: Jun 20, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
Published on: January 25, 2015
Upper gastrointestinal bleeding from metastatic testicular cancer
Adeyinka O Laiyemo1, Momodu Jack, Fitzroy W Dawkins
1Cancer Prevention Fellowship Program, Office of Preventive Oncology, Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, 6130 Executive Blvd, Rm 3121, Bethesda, MD 20892-7354, USA. laiyemoa@mail.nih.gov
Abstract:
We report a 22-year-old man who presented with a 2-week history of intermittent melena and worsening scrotal and leg swelling. His medical history was significant for testicular cancer for which he had undergone orchiectomy, lymphadenectomy, and platinum-based chemotherapy. Esophagogastroduodenoscopy (EGD) performed revealed polypoid mass lesions in the second and third portions of the duodenum. Biopsy revealed mixed germ cell tumor with immature teratoma, the same histology as his testicular cancer. His chemotherapy was changed to an ifosphamide-based regimen and a repeat upper endoscopic examination 5 months later revealed complete resolution of previously noted polypoid duodenal mass lesions. This also demonstrates the effectiveness of ifosphamide as second-line therapy in the setting of resistance to platinum-based therapy.
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