Biochemical markers of joint tissue turnover
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Updated: Jun 20, 2026
Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
Published on: January 27, 2023
Anne-Christine Bay-Jensen1, Bodil Cecilie Sondergaard, Claus Christiansen
1Nordic Bioscience A/S, Herlev, Denmark.
Abstract:
Recent disappointments in late stage developments of anti-osteoarthritic drugs have reinforced efforts to develop better biomarkers for application in both the drug development process as well as in the routine management of these patients. Here we provide a brief review of biochemical tests available for the study of tissue turnover in each of the three compartments of the articular joint, that is the bone, the cartilage, and the synovium. Finally, we provide some perspective to future developments in biomarker discovery and discuss the potential impact such technologies could have on the drug development process.
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