Related Experiment Video

Updated: Jun 20, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Therapeutic failure in a renal transplant patient with Pneumocystis jiroveci pneumonia: a case report

Nikolaos K Archontoulis1, Chryssoula V Staikou

  • 1Intensive Care Unit, Laiko General Hospital, Aretaieio Hospital, 11528 Athens, Greece.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|September 1, 2009
PubMed
Abstract

Insights

Pneumocystis jiroveci pneumonia is a serious risk for immunocompromised patients. A renal transplant recipient experienced fatal complications despite treatment, highlighting potential drug resistance.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Transplantation Medicine

Background:

  • Pneumocystis jiroveci pneumonia (PJP) is a significant opportunistic infection in immunocompromised individuals.
  • Renal transplant recipients are at high risk due to long-term immunosuppression.

Observation:

  • This case report details a patient who developed PJP six months post-renal transplant.
  • The patient suffered severe pneumonia-related complications and adverse drug reactions.

Findings:

  • Treatment failure occurred despite the use of multiple antibiotic agents, including the recommended co-trimoxazole.
  • The patient ultimately died due to complications of PJP.

Implications:

  • This case underscores the challenges in treating PJP in transplant patients.
  • It raises critical concerns regarding the potential emergence of P jiroveci resistance to established therapies.

More Related Videos

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation06:15

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection06:59

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

Published on: February 2, 2022

Related Concept Videos

Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...