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Updated: Jun 20, 2026

Cell Population Analyses During Skin Carcinogenesis

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

[Post-traumatic basal cell carcinoma associated with patch testing].

M T Bordel-Gómez¹, A Miranda-Romero

¹Complejo Asistencial Virgen de la Concha, Zamora, España. maitebordel@aedv.es

Actas Dermo-Sifiliograficas

|September 1, 2009

Summary

This summary is machine-generated.

Basal cell carcinoma, a common skin cancer, may be linked to metal sensitization. A patient developed this cancer at a gold patch test site, with gold particles found in the skin.

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Last Updated: Jun 20, 2026

Cell Population Analyses During Skin Carcinogenesis

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Area of Science:

Dermatology
Oncology
Toxicology

Background:

Basal cell carcinoma (BCC) is the most prevalent human epithelial skin cancer, typically affecting older individuals.
While ultraviolet (UV) radiation is a primary cause, other factors like trauma may contribute to BCC development.
Metal sensitization, leading to contact dermatitis, is an emerging area of dermatological research.

Observation:

A case study involving a woman with a history of metal sensitization and contact dermatitis.
The patient developed superficial basal cell carcinoma (BCC) at the precise location of a prior gold chloride patch test.
The patch test, conducted 30 months before BCC diagnosis, was strongly positive for gold chloride.

Findings:

Histological examination using a scanning electron microscope revealed electron-dense particles within the dermis at the tumor site.
These particles were subsequently identified as gold.
This suggests a potential link between gold exposure and localized BCC development.

Implications:

The findings suggest that metal sensitization, specifically to gold, could be a contributing factor in the pathogenesis of basal cell carcinoma.
This case highlights the importance of considering environmental and occupational exposures, including metals, in skin cancer development.
Further research is warranted to explore the mechanisms by which metals might influence skin carcinogenesis and to assess the prevalence of metal-related BCC.