Effect of microporous polysaccharide hemospheres (MPH) on bleeding after endoscopic sinus surgery: randomized...

Area of Science:

• Otolaryngology
• Surgical Innovation
• Hemostasis

Background:

• Absorbable hemostatic agents are frequently employed following endoscopic sinus surgery (ESS).
• Microporous polysaccharide hemospheres (MPH) represent a novel, rapidly absorbed hemostatic powder.
• Evaluating new hemostatic agents is crucial for optimizing surgical outcomes.

Purpose of the Study:

• To assess the efficacy of MPH in controlling bleeding after ESS.
• To compare bleeding, pain, obstruction, and nasal discharge in MPH-treated versus untreated sinonasal cavities.

Main Methods:

• A randomized, controlled, single-blinded study was conducted at a tertiary university hospital.
• Patients undergoing bilateral ESS were treated unilaterally with MPH post-surgery, with the contralateral side serving as a control.
• Symptom severity, including bleeding, was assessed using visual analog scales (VAS) up to postoperative day 30.

Main Results:

• Forty patients were included, with no reported complications and same-day discharge.
• MPH-treated sides showed significantly reduced bleeding on postoperative day one (mean score 22.5 vs. 39.0 for controls, P < 0.0001).
• No significant differences were observed in bleeding at other time points or in pain, obstruction, or nasal discharge between groups.

Conclusions:

• MPH effectively reduces early postoperative bleeding after ESS.
• The use of MPH does not lead to increased pain, obstruction, or nasal discharge.
• MPH facilitates a normal postoperative recovery trajectory when used after ESS.