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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

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Related Experiment Video

Updated: Jun 20, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

Polypharmacy in the elderly: a multicenter study.

Yesim Gokce Kutsal1, Anil Barak, Ayce Atalay

  • 1Hacettepe University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Ankara, Turkey. ykutsal@hacettepe.edu.tr

Journal of the American Medical Directors Association
|September 1, 2009
PubMed
Summary

Polypharmacy in Turkish elderly is linked to age, sex, marital status, and chronic conditions, but not education level. This highlights key factors influencing medication use in older adults.

Related Experiment Videos

Last Updated: Jun 20, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

Area of Science:

  • Gerontology
  • Public Health
  • Pharmacoeconomics

Background:

  • Polypharmacy, the concurrent use of multiple medications, is a significant concern in elderly populations worldwide.
  • Understanding the factors associated with polypharmacy is crucial for developing targeted interventions.
  • Socioeconomic variables can influence medication management and adherence in older adults.

Purpose of the Study:

  • To investigate the prevalence of polypharmacy among Turkish elderly patients.
  • To examine the relationship between polypharmacy and various socioeconomic and demographic factors in this population.

Main Methods:

  • A cross-sectional study was conducted with 1430 elderly patients from outpatient clinics across 12 Turkish provinces.
  • Data were collected via interviews using a questionnaire covering demographics, medical diagnoses, and current medications.
  • Variables included age, gender, marital status, education, retirement status, number of children, and chronic disease presence.

Main Results:

  • The mean number of drugs used was higher in females.
  • Significant correlations were found between polypharmacy and age groups, marital status, number of children, retirement status, and presence of chronic disease.
  • No significant association was observed between polypharmacy and educational status.

Conclusions:

  • Polypharmacy in Turkish elderly is associated with age, sex, marital status, number of children, retirement status, and chronic medical conditions.
  • Educational status was not found to be a significant factor in polypharmacy within this study group.
  • These findings underscore the multifactorial nature of polypharmacy and inform potential public health strategies for medication management in older adults.