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Related Experiment Video

Updated: Jun 20, 2026

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
13:00

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Published on: April 17, 2012

Preterm labor biomarker discovery in serum using 3 proteomic profiling methodologies.

Caroline L Stella1, Michael R Bennett, Prasad Devarajan

  • 1Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH, USA.

American Journal of Obstetrics and Gynecology
|September 1, 2009
PubMed
Summary

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Researchers identified protein expression changes in preterm labor using proteomic methods. These findings may help identify women at risk for preterm delivery.

Area of Science:

  • Proteomics
  • Biochemistry
  • Obstetrics

Background:

  • Preterm labor is a significant concern in pregnancy.
  • Identifying biomarkers for preterm labor is crucial for timely intervention.

Purpose of the Study:

  • To investigate protein expression differences in normal pregnancy versus preterm labor.
  • To identify potential protein biomarkers for predicting preterm delivery.

Main Methods:

  • Utilized three proteomic techniques: surface-enhanced laser desorption ionization (SELDI), matrix-assisted laser desorption ionization (MALDI), and 2-dimensional electrophoresis (2DE).
  • Analyzed serum samples from nonpregnant women and pregnant women with various labor conditions (preterm labor with preterm delivery, preterm labor with term delivery, term labor, and term contractions).

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Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
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Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

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Last Updated: Jun 20, 2026

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
13:00

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Published on: April 17, 2012

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
10:05

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

Main Results:

  • SELDI identified significant peak differences between preterm labor groups and term labor groups.
  • Specific m/z peaks (7783.2 and 3164) were significantly altered in preterm labor with preterm delivery compared to preterm labor with term delivery.
  • 2DE revealed significant protein differences between preterm labor with preterm delivery and term labor with delivery.
  • MALDI detected a notable difference at 55,000 m/z between preterm labor with preterm delivery and term labor with delivery.

Conclusions:

  • SELDI successfully identified two proteins meeting criteria for putative biomarkers.
  • These identified biomarkers may assist in predicting which women experiencing preterm labor are likely to deliver preterm.