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Updated: Jun 20, 2026

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis
Published on: August 20, 2020
A ryanodine receptor agonist promotes the consolidation of long-term memory in young chicks
Kathryn D Baker1, Thomas M Edwards, Nikki S Rickard
1School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, 3800 Victoria, Australia. Kathryn.Baker@med.monash.edu.au
Abstract:
Young chicks were trained on a weakly reinforced variant of a single-trial discrimination avoidance task which typically fails to consolidate the long-term memory stage. The ryanodine receptor (RyR) agonist 4-chloro-m-cresol (500 microM, i.c.) persistently promoted high retention until at least 24 h post-training when administered between the time of training and 20 min post-training. The consolidation of the long-term memory stage by RyR activation implicates intracellular calcium release in triggering long-term memory.
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