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Neuroleptic malignant syndrome and acute motor axonal neuropathy after Campylobacter jejuni infection

Y A Rajabally1, A Ramlackhansingh, M Fraser

  • 1Department of Neurology, Neuromuscular Clinic, Leicester General Hospital, University Hospitals of Leicester, Leicester LE5 4PW, United Kingdom. yusuf.rajabally@uhl-tr.nhs.uk

Neurophysiologie Clinique = Clinical Neurophysiology
|September 1, 2009
PubMed

Insights

A patient with Parkinson's disease developed acute motor axonal neuropathy (AMAN) after neuroleptic malignant syndrome (NMS). This post-infectious condition, linked to Campylobacter jejuni, responded well to immunoglobulin therapy.

Area of Science:

  • Neurology
  • Immunology
  • Infectious Diseases

Background:

  • Neuroleptic Malignant Syndrome (NMS) is a rare, life-threatening reaction to antipsychotic medications.
  • Acute Motor Axonal Neuropathy (AMAN) is an autoimmune disorder affecting peripheral nerves.
  • Parkinson's disease patients may have unique vulnerabilities to neurological complications.

Observation:

  • A patient with Parkinson's disease experienced rapid limb weakness following NMS.
  • The patient had serologic evidence of a preceding Campylobacter jejuni infection.
  • Symptoms of AMAN appeared days after the NMS episode.

Findings:

  • The co-occurrence of NMS and AMAN suggests a potential post-infectious immune-mediated process.
  • Campylobacter jejuni infection is a known trigger for AMAN.
  • Intravenous immunoglobulin therapy was effective in treating the neuropathy.

Implications:

  • This case highlights a potential link between NMS, Campylobacter jejuni infection, and AMAN.
  • Neuropathies associated with NMS may be immunologically mediated and treatable with immunomodulatory therapies.
  • Further research is warranted to understand the pathogenesis and management of these rare neurological complications.

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