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Related Concept Videos

Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Apparent Weight01:09

Apparent Weight

True weight is the measure of the gravitational force acting on an object. However, if the object accelerates, its measured weight is different from its true weight. Similar observations can be made when the object is submerged in water. An object's weight in water is its apparent weight, which is equal to the difference between its true weight and the buoyant forces.
Consider a person standing on a bathroom scale inside an elevator. If the scale is accurate at rest, its reading equals the...
Protein Transport into the Inner Mitochondrial Membrane01:34

Protein Transport into the Inner Mitochondrial Membrane

Nuclear encoded mitochondrial precursors are imported to the inner membrane in a multistep process involving two separate translocons, TIM22 and TIM23. TIM23 is a cation-selective pore that remains closed by the N terminal segment of the protein. Negative charges on the TIM23 act as a receptor for the incoming precursor, pulling the positively charged matrix-targeting sequence for peptide insertion and translocation.
Transport of mitochondrial precursors across the TIM23 channel is driven by...

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Related Experiment Video

Updated: Jun 20, 2026

A Guide to Examining Intramuscular Fat Formation and its Cellular Origin in Skeletal Muscle
09:19

A Guide to Examining Intramuscular Fat Formation and its Cellular Origin in Skeletal Muscle

Published on: May 26, 2022

Putative fat fighter hits the middle man.

James Robert Krycer1, Andrew John Brown

  • 1University of New South Wales, Sydney, Australia.

Chemistry & Biology
|September 1, 2009
PubMed
Summary

Fatostatin, a novel compound, inhibits sterol regulatory element-binding proteins (SREBPs) which control lipid levels. This laboratory tool improved lipid profiles in obese mice, suggesting potential clinical applications for metabolic disorders.

Area of Science:

  • Biochemistry
  • Metabolic research
  • Pharmacology

Background:

  • Sterol regulatory element-binding proteins (SREBPs) are key regulators of lipid homeostasis.
  • Developing targeted inhibitors for SREBP activity is a significant area of metabolic research.

Discussion:

  • Fatostatin effectively inhibits SREBP activity, acting as a valuable laboratory tool.
  • The compound demonstrated efficacy in improving lipid profiles in a preclinical model of obesity.

Key Insights:

  • Fatostatin's mechanism involves direct inhibition of SREBP function.
  • Preclinical data suggests fatostatin's potential to ameliorate dyslipidemia associated with obesity.

Outlook:

  • Further investigation is warranted to explore fatostatin's therapeutic potential in human metabolic diseases.

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Last Updated: Jun 20, 2026

A Guide to Examining Intramuscular Fat Formation and its Cellular Origin in Skeletal Muscle
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  • Clinical translation of fatostatin could offer new strategies for managing lipid disorders.