Related Experiment Video
Updated: Jun 20, 2026
The Establishment of a Murine Maxillary Orthodontic Model
Published on: October 27, 2023
Preclinical animal model for de novo bone formation in human maxillary sinus
Karl Andreas Schlegel1, Stephan Rupprecht, Ljubinko Petrovic
1Department of Oral and Maxillofacial Surgery, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Objectives:
Up to now the effect of bone-substitute materials on de novo bone formation has been tested in a variety of preclinical animal models. We hypothesized that there is no significant difference in bone regeneration after application of autogenous bone (AB) and bone substitutes in a porcine calvarial monocortical defect model and in human maxillary sinus.
Study Design:
Twenty-four weeks after application of ss-tricalcium phosphate (betaTCP), hydroxyapatite (HA), and AB in each of 3 defects on the sculls of 6 adult pigs (N = 54) and the application in 44 sinus floor elevations (11x betaTCP, 6x HA and 24x AB) in 41 patients, bone regeneration rates where compared microradiographically. Wilcoxon rank-sum test was used for statistical analysis.
Results:
Comparing the human with the animal specimens microradiographically, no significant difference of the mineralization rate could be found.
Conclusion:
The chosen porcine model is a valuable method for preclinical testing of bone-substitute materials in maxillofacial surgery.
