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Drug loaded poly[Lac(Glc-Leu)] microparticles: formulation and release characteristics
Sagar M Agnihotri1, Pradeep R Vavia
1Pharmaceutical Division, Institute of Chemical Technology, University of Mumbai, Nathalal Parikh Street, Matunga, Mumbai 400019, India. agnihotrisagar@hotmail.com
Colloids and Surfaces. B, Biointerfaces
|September 1, 2009
Summary
Researchers developed sub-5 micrometer valdecoxib particles using poly[Lac(Glc-Leu)] copolymer. Formulation parameters were optimized to control particle size and achieve monodispersed microparticles for potential drug delivery applications.
Area of Science:
- Polymer science
- Materials science
- Pharmaceutical technology
Background:
- Valdecoxib is a non-steroidal anti-inflammatory drug.
- Controlling particle size is crucial for drug delivery systems.
- Polymeric microparticles offer potential for controlled drug release.
Purpose of the Study:
- To encapsulate valdecoxib into poly[Lac(Glc-Leu)] copolymer microparticles.
- To investigate the influence of formulation parameters on microparticle characteristics.
- To achieve monodispersed sub-5 micrometer particles.
Main Methods:
- Oil-in-water (o/w) emulsification-solvent evaporation technique.
- Microfluidizer used as an ultrasonication device for monodispersity.
- Systematic variation of polymer load, ultrasonication time, stabilizer concentration, and stirring rate.
Main Results:
- Successfully entrapped valdecoxib into poly[Lac(Glc-Leu)] microparticles.
- Demonstrated that formulation parameters significantly affect particle size and polydispersity.
- Achieved microparticles ranging from 0.8 to over 4 micrometers.
Conclusions:
- The emulsification-solvent evaporation method is effective for preparing valdecoxib-loaded microparticles.
- Optimization of formulation parameters allows for control over microparticle size and distribution.
- The developed microparticles show potential for pharmaceutical applications.
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