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Updated: Jun 20, 2026
09:07
Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
Published on: January 20, 2017
Functional association between influenza A (H1N1) virus and human
Tao Huang1, WeiRen Cui, Zhi-Song He
1Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China.
Biochemical and Biophysical Research Communications
|September 1, 2009
Summary
Influenza A (H1N1) virus poses a global threat. This study identified 101 core host proteins targeted by the virus, revealing mechanisms of viral infection and host responses.
Area of Science:
- Virology
- Computational Biology
- Immunology
Background:
- Influenza A (H1N1) virus presents a significant worldwide health concern.
- Understanding the intricate mechanisms of viral infection and host-pathogen interactions is crucial.
Purpose of the Study:
- To develop a computational framework for investigating virus-host crosstalk.
- To identify specific host proteins targeted by Influenza A (H1N1).
Main Methods:
- Established a computational approach to predict virus-targeted proteins.
- Identified host proteins sharing Gene Ontology (GO) functions or processes with viral proteins.
Main Results:
- Identified 101 core host proteins as potential targets of Influenza A (H1N1).
- The findings shed light on biological processes and molecular interactions during infection.
Conclusions:
- The study provides insights into host responses to Influenza A (H1N1) infection.
- The identified proteins offer potential targets for understanding and combating viral pathogenesis.
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