Related Experiment Video
Updated: Jun 20, 2026

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety
Published on: November 11, 2022
Developments in the treatment and diagnosis of anxiety disorders
Hans-Ulrich Wittchen1, Andrew T Gloster
1Institute of Clinical Psychology & Psychotherapy, Department of Psychology, Technische Universität Dresden, Chemnitzer Strasse 46, D-01187 Dresden, Germany. wittchen@psychologie.tu-dresden.de
Abstract:
Anxiety disorders occur frequently, begin at an early age, significantly impair patients' lives, and are often associated with other comorbid conditions. Despite impressive improvements in the treatment of anxiety disorders in the last decade, the mechanisms leading to comorbidity and the processes responsible for therapeutic change remain unclear. Within this context, clear and precise definitions of the putative active ingredients are needed in order to further improve treatments. This article reviews these critical issues and sets the stage for the other articles in this special issue.
Related Concept Videos
Behavior Therapy
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Theoretical Approaches to Psychological Disorder
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Diagnostic and Statistical Manual of Mental Disorders (DSM)
Drug Therapy
Antianxiety Medications
Anxiolytic Drugs: Overview
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic circuitry.
