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Elevated visfatin/pre-B-cell colony-enhancing factor plasma concentration in ischemic stroke.
Li-Fen Lu1, Sheng-Shan Yang, Chao-Ping Wang
1Division of Cardiac Surgery, Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Summary
Higher levels of visfatin, a proinflammatory cytokine, are significantly associated with an increased risk of ischemic stroke. This finding highlights visfatin as a potential biomarker for stroke risk assessment.
Area of Science:
- Biochemistry
- Immunology
- Cardiovascular Research
Background:
- Visfatin (pre-B-cell colony-enhancing factor) is a cytokine found in various tissues, including adipose tissue.
- It is known to promote inflammatory responses and vascular smooth cell maturation.
- Visfatin's potential role as a proinflammatory cytokine in atherosclerosis necessitates further investigation.
Purpose of the Study:
- To determine if plasma visfatin levels are altered in patients diagnosed with ischemic stroke.
- To explore the association between visfatin concentrations and the risk of ischemic stroke.
Main Methods:
- Plasma visfatin concentrations were quantified using enzyme immunoassays.
- The study included 120 patients with ischemic stroke and 120 healthy control subjects.
- Statistical analyses, including multiple logistic regression, were employed to assess associations.
Main Results:
- Mean plasma visfatin levels were significantly higher in ischemic stroke patients compared to controls (51.5 vs. 23.0 ng/mL, P < .001).
- Elevated visfatin was identified as an independent risk factor for ischemic stroke.
- A dose-dependent relationship was observed, with higher visfatin quartiles correlating with increased stroke risk (ORs ranging from 2.3 to 20.1).
- Plasma visfatin showed positive correlation with high-sensitivity C-reactive protein and negative correlation with LDL cholesterol.
Conclusions:
- Elevated plasma visfatin levels are significantly associated with ischemic stroke in the studied Chinese population.
- These findings suggest visfatin may serve as a valuable biomarker for ischemic stroke risk.
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