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Updated: Jun 20, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Severe allergic reaction to Dermabond.

Arthur W Perry¹, Michael Sosin

¹Division of Plastic Surgery, Robert Wood Johnson Medical School, New Brunswick, NJ, USA. arthurwperrymd@mac.com

Aesthetic Surgery Journal

|September 1, 2009

Summary

2-octyl cyanoacrylate, commonly known as Dermabond, is a popular wound closure adhesive. While usually safe, this article details a severe allergic reaction to Dermabond after breast augmentation surgery.

Area of Science:

Plastic Surgery
Dermatology
Allergy & Immunology

Background:

2-octyl cyanoacrylate (Dermabond) is a widely utilized topical adhesive for surgical wound closure.
Its use is prevalent in various procedures, including cosmetic surgeries like breast augmentation and mastopexy.
Adverse events are typically linked to application errors rather than intrinsic adhesive properties.

Observation:

A patient experienced a severe allergic reaction subsequent to the application of Dermabond for wound closure.
The reaction occurred following a breast augmentation/mastopexy procedure.
This case highlights a rare but significant complication associated with the cyanoacrylate adhesive.

Findings:

The patient presented with signs of a severe allergic response attributed to Dermabond.

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Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response

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Published on: October 3, 2019

The allergic reaction was noted despite the generally favorable safety profile of topical adhesives.

This underscores the potential for idiosyncratic reactions to 2-octyl cyanoacrylate.

Implications:

Clinicians should be vigilant for rare allergic reactions to 2-octyl cyanoacrylate, even in routine applications.
Understanding potential adverse events is crucial for patient safety in plastic and reconstructive surgery.
This case emphasizes the need for thorough patient evaluation and monitoring for hypersensitivity to surgical adhesives.