Related Experiment Video
Updated: Jun 20, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
Voice onset time in Parkinson disease
Emily Fischer1, Alexander M Goberman
1Department of Communication Sciences and Disorders, 200 Health Center Building, Bowling Green State University, Bowling Green, OH 43403-0149, USA. emilybud@gmail.com
This study examined voice onset time (VOT) and VOT ratio in Parkinson disease (PD). Results show medication affects VOT more than VOT ratio, distinguishing rate-related from true changes in PD speech.
Area of Science:
- Speech-language pathology
- Neuroscience
- Linguistics
Background:
- Speaking rate is affected by Parkinson disease (PD).
- Speaking rate influences voice onset time (VOT).
- Understanding speech changes in PD is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate voice onset time (VOT) and VOT ratio in individuals with PD.
- To differentiate rate-related VOT changes from true VOT alterations in PD.
- To assess the impact of PD medication on VOT and VOT ratio.
Main Methods:
- Examined VOT and VOT ratio in 9 individuals with PD and 9 controls.
- Measurements were taken before and after PD medication.
- Analysis considered place of articulation and vowel height.
Main Results:
- Place of articulation and vowel height significantly impacted VOT and VOT ratio for all participants.
- No significant differences in VOT or VOT ratio were found between individuals with PD and controls.
- PD medication demonstrated a more pronounced effect on VOT compared to VOT ratio.
Conclusions:
- Examining both VOT and VOT ratio is valuable for individuals with PD.
- This approach helps distinguish between rate-related and true changes in VOT.
- Findings support the use of VOT ratio to better understand speech production in PD.
Related Concept Videos
Parkinson Disease l: Introduction
Parkinson's Disease: Overview
Parkinson Disease ll: Pathophysiology
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Alterations in Muscle Tone lll
Time-Domain Interpretation of PD Control
Consider the example of control of motor torque. Initially, a positive...

